Precision medicine is a developing approach in the health sector that takes into account an individual’s genes, environment, and lifestyle for disease diagnosis, treatment, and prevention. The 2016-17 Governor’s Budget proposes to make a one-time appropriation of $10 million from the state General Fund to OPR to fund precision medicine research. We find that the Governor’s proposal lacks key details and a clear justification. In the absence of this information, we recommend the Legislature reject the Governor’s proposal.